What is Aleve? Aleve is used to relieve pain from various conditions such as headache, muscle aches, dental pain, menstrual cramps, or arthritis. It is also used to reduce fever and relieve minor aches and pain due to the common cold or flu. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.