What is Famotidine? Famotidine, sold under the trade name Pepcid among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. Famotidine may also be used for purposes not listed in this medication guide.

What is the dosage for Famotidine?

  • The recommended adult oral dose for treating duodenal ulcers is 40 mg once daily at bedtime or 20 mg twice daily. Most patients heal their ulcers within 4 weeks. The regimen for maintenance therapy after the ulcers are healed is 20 mg once a day at bedtime. The recommended oral dose for adults with gastric ulcers is, 40 mg once daily at bedtime.
  • Esophagitis is treated with 20 or 40 mg twice daily for up to 12 weeks. Zollinger-Ellison syndrome is treated with 20 mg every 6 hours, and doses up to 160 mg every 6 hours have been used in some patients.
  • GERD is treated with 20 mg twice daily for up to 6 weeks. Occasional heartburn is treated with 10-20 mg daily administered 15 to 60 minutes before ingestion of food or beverages that cause heartburn.