How to take Alendronate. Take Alendronate first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take Alendronate only once per week, take it on the same day each week and always first thing in the morning. Take with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup.