Alendronate serious side effects. Stop using Alendronate and call your doctor at once if you have a serious side effect such as:

  • chest pain
  • difficulty or pain when swallowing
  • pain or burning under the ribs or in the back
  • severe heartburn, burning pain in your upper stomach, or coughing up blood
  • new or worsening heartburn
  • fever, body aches, flu symptoms
  • severe joint, bone, or muscle pain
  • new or unusual pain in your thigh or hip
  • jaw pain, numbness, or swelling