What is Tiotropium? Tiotropium (originally marketed as Spiriva) is a long-acting, 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium inhalation is also used to prevent asthma attacks in adults and children who are at least 6 years old. Tiotropium inhalation may also be used for purposes not listed in this medication guide.