What is Topiramate? Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug. Topiramate is a seizure medicine, also called an anticonvulsant. Topiramate is used to treat seizures in adults and children who are at least 2 years old. Trokendi XR is for use in adults and children who are at least 6 years old. Extended-release topiramate has a higher minimum age (at least 10 years old) when used as the child’s only seizure medicine.