How to take Venlafaxine. Venlafaxine should be taken with food. Try to take your dose at the same time each day. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. To make the extended-release capsule easier to swallow, you may open the capsule and sprinkle the medicine into a small amount of applesauce. Swallow all of the mixture without chewing, and do not save any for later use.